18.09.2015

siRNA Delivery Kit Delivery System for siRNA/DNA from Avanti Polar Lipids, Inc.

The self-assembly of custom-synthesized MVL5 and GMO with siRNA results in the formation of a double-gyroid bicontinuous inverted cubic phase with colocalized lipid/siRNA domains. The high charge density (due to MVL5) and positive Gaussian modulus of the GMO-containing membranes confer optimal electrostatic and elastic properties for endosomal escape, enabling efficient siRNA delivery and effective, specific gene silencing.

Reference
Leal, C., K.K. Ewert, R.S. Shirazi, N.F. Bouxsein, and C.R. Safinya. (2011). Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir 27:7691-7. [PubMed]



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Visit the manufacturer page at www.stratech.co.uk/avanti-polar-lipids, email info@stratech.co.uk or call +44 (0) 1638 782600.

Stratech Scientific is a distributor of high quality, competitively priced, reliable products for research laboratories throughout the UK and Europe. Please contact us to find out which ranges we can supply in your country.