OAS3 Antibody, Biotin conjugated

Catalogue Number: CSB-PA897591LD01HU-CSB

Manufacturer:	Cusabio Biotech
Preservative:	0.03% ProClin™ 300
Ph:	7.4
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 50 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Recombinant Human 2'-5'-oligoadenylate synthase 3 protein (424-565AA)
Application:	ELISA

Overview
Datasheets

Description

Description: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

Additional Text

Uniprot ID

Q9Y6K5

Gene Name

OAS3

Purification

Protein G purified

Gene ID

4940

Antibody Clonality

Polyclonal

Specificity

(2-5'')oligo(A) synthase 3 antibody; 2 5' oligo(A) synthetase 3 antibody; 2 5'LIGO antibody; 2 5A synthetase 3 antibody; 2''-5''-oligoadenylate synthase 3 antibody; 2-5A synthase 3 antibody; MGC133260 antibody; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa antibody; OAS3 antibody; OAS3_HUMAN antibody; p100 antibody; p100 OAS antibody; p100OAS antibody

CSB-PA897591LD01HU Datasheet

Price

£227.00

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Quantity
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