Catalogue Number: S8419-SEL
Manufacturer: | Selleck Chemicals |
Type: | Other Inhibitors |
Shipping Condition: | Blue Ice |
Unit(s): | 5 mg, 25 mg |
Description: Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.