qDBS Technology

We’ve developed qDBS technology, a microfluidic technology that offers a solution for easy and accurate Self Sampling.

All Capitainer blood sampling cards are built on our qDBS technology. It uses a combination of paper, polymer microfluidics and thin water-soluble membranes to meter a fixed volume of blood. After applying blood to the inlet, a metering channel in the device is automatically filled and the blood is transferred to a pre-cut DBS paper disc.

In the 10µL version, one blood drop is added to the inlet and a double valve solution is applied where a thin dissolvable membrane opens up after blood application and removes excessive blood at the inlet. Subsequently, a second membrane opens up , allowing for transfer of the metered blood volume onto the sample collection disk at the outlet.

The 50µL version applies a single valve solution with another filling mechanism, to allow application of multiple drops.

The sample is allowed to dry forming a high quality DBS sample suitable for quantitative analysis.

The metering mechanism employing thin dissolvable films was first demonstrated by G. Lenk et al 

In Capitainer®B a double valve solution is applied to discard excess blood and deliver the metered 10µL to the sample disc

Evaluation Study

Manual Pipetting of Blood vs Capitainer® Collection


  • EDTA-blood was collected from a coffee drinker by venous puncture
  • 25 µL of blood was applied to 20 Capitainer® channels
  • For reference 10 µL of blood was applied by manual displacement pipetting to 20 discs removed from Capitainer®qDBS devices
  • Caffeine concentration was measured in all samples by an accredited LC-MS/MS method


  • Caffeine concentration coefficient of variation for Capitainer® was 2,84% vs 6,25% for manual pipetting

Source: Evaluation study by Dr Olof Beck, Analysis of caffeine by LC-MS/MS method. 2020 March 16

Similar results were obtained in a study by Spooner et al


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