Nucleosides for Applications on Proteins/Enzymes – Sulfonyl Fluoride Probes

Sulfonyl fluorides are covalent probes for enzyme binding sites and assess functionally important protein residues. They possess desirable electrophilicity that enables capture of context specific amino acid reactivity whilst retaining appropriate aqueous stability commensurate with biomolecular experiments. Sulfonyl fluoride electrophiles target active serine, threonine, tyrosine, lysine, cysteine and histidine residues.[1,2]


Name Cat. No. Size
5′-O-(4-fluorosulfonylbenzoyl)-adenosine N-1086-2 2 mg
5′-O-(4-fluorosulfonylbenzoyl)-adenosine N-1086-10 10 mg
5′-O-(4-fluorosulfonylbenzoyl)-guanosine N-1085-2 2 mg
5′-O-(4-fluorosulfonylbenzoyl)-guanosine N-1085-10 10 mg

Selected References

[1] Narayanan et al. (2015) Sulfonyl fluorides as privileged warheads in chemical biology. Chem. Sci. 6:2650.
[2] Dong et al. (2014) Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry. Angew. Chem. Int. Ed. Engl. 53(36):9430.


outstanding technical support


we offer a full product guarantee


we offer free delivery to UK universities and non profit organisations