Endoplasmic reticulum stress induces hepatic plasminogen activator inhibitor 1 in murine nonalcoholic steatohepatitis

The authors of A publication utilized the mouse PAI-1 total antigen assay ELISA kit from Molecular Innovations.

“PAI‐1 is a stress‐responsive gene that is highly induced in nonalcoholic steatohepatitis (NASH). Endoplasmic reticulum (ER) stress is a salient feature of NASH, yet it is unknown whether ER stress contributes to hepatic PAI‐1 induction in this disorder. Hepatic PAI-1 expression was measured in mice subjected to pharmacologic ER stress.”

PAI-1 antigen levels in mouse plasma and liver tissue homogenates were determined after treatment with tunicamycin to induce prolonged low‐grade ER stress. Hepatic and plasma PAI-1 concentrations were increased 72 hours after induction of ER stress.


outstanding technical support


we offer a full product guarantee


we offer free delivery to UK universities and non profit organisations