nanocomposix covid-19

Research Solutions for Coronavirus – Nanocomposix

Coronavirus Disease 2019 (COVID-19) Response

In light of the impact from COVID-19, we have seen an increasing demand for reagents essential to lateral flow assays and point-of-care test development from our customers. Rapid diagnosis is a critical tool for screening at-risk populations and managing the spread of the outbreak. Development of sensitive lateral flow assays requires high performance, robust gold particles, and our BioReady gold reagents are a key component for maximizing the sensitivity and reliability of visual detection point of care tests.
Given the growing demand, we would like to support our customers in efforts to address the global community’s urgent need for rapid point-of-care testing.

New to covalent conjugation? Need increased assay sensitivity?

Imagine an optimized system with time-after-time consistency that provides increased sensitivity and saves you time and money!

The High Sensitivity Conjugation Kit is a complete “classroom-in-a-box” with detailed protocols to help you produce robust covalently-bound conjugates. This kit is available with our ultra-bright 150 nm gold nanoshells as the reporter particle and includes everything you need to optimize your conjugations.

Benefits of the kit include:

  • Pre-validated consumables eliminate the risk of purchasing non-compatible reagents, saving weeks to months of unnecessary troubleshooting
  • Increase your assay sensitivity up to 20-fold with 150 nm gold nanoshells compared to 40 nm gold* nanoparticles
  • Reduces antibody costs up to 65% compared to physisorption
  • Saves time by reducing the number of conjugations necessary to find optimal antibody pairs

Already a conjugation expert? This kit eliminates the need to pre-screen and validate critical reagents and supplies to ensure your best chance of success when starting out with covalent conjugation to gold nanoshells.

Kit includes 10 mL of BioReady 150 nm Gold Nanoshells with a carboxyl surface, provided at 20 OD. Contact us to order the kit with BioReady 40 or 80 nm Gold Nanospheres.

TEM Diameter: 155 nm ± 15 nm
Size Distribution (CV): ≤ 15%

Note: approximate ranges below are dependent on diameter

  • Hydrodynamic diameter (DLS): TEM diameter plus 5 to 25 nm
  • Zeta potential: –40 to –70 mV
  • pH of solution: 6.0 to 9.5
  • Particle surface: carboxyl
  • Solvent: 0.02 mM potassium carbonate solution
  • Peak wavelength (λmax): 770 to 840 nm

nanoComposix Gold Conjugation Kit offers the advantage of covalent binding in two different gold sizes – 40 nm and 80 nm – to quickly screen and optimize gold conjugates for robust, high-performing lateral flow assays.

This kit eliminates the need to pre-screen and validate critical reagents and supplies to ensure your best chance of success. Kit components include:

  • BioReady carboxyl 40 nm or 80 nm gold particles, 20 OD
  • Desalting column for removal of interfering reagents (NaCl, azide, tris, glycine)
  • EDC and Sulfo-NHS
  • All buffers necessary to complete the conjugation
  • Step-by-step conjugation procedure and optimization

No experience needed! Our kit is the optimal solution for conjugation experts and anyone new to lateral flow looking to improve existing tests or develop the next novel LF assays.

TEM DiameterSize Distribution (CV)
80 nm ± 5 nm≤ 15%
40 nm ± 4 nm≤ 15%

Note: approximate ranges below are dependent on diameter

  • Hydrodynamic diameter (DLS): TEM diameter plus 0 to 30 nm
  • Zeta potential: –25 to –80 mV
  • pH of solution: 5.5 to 7.0
  • Particle surface: PEG12-carboxylic acid
  • Solvent: Milli-Q water
  • Peak wavelength (λmax): 525 to 545 nm

BioReady Flyers

Research Solutions for Coronavirus – Nanocomposix
Research Solutions for Coronavirus – Nanocomposix

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