50% on Ubiquitin / Deubiquitinating Enzymes

6 months half price on ubiquitin Proteins, ubiquitin enzymes and deubiquitinases – offer expires on 16th of September 2020

Use code UBI-50

Helping Targeted Protein Degradation Research to better understand the cell’s ubiquitin related proteolysis machinery and mechanism.

Protein modifications by ubiquitin (Ub) or ubiquitin-like proteins (UBLs) participate in many critical cellular processes such as cell-cycle regulation, DNA repair, oncogenesis, antiviral pathways and most notably, proteasomal degradation of target proteins. Ubiquitination and modification by UBLs share a similar catalytic cascade which requires the sequential action of three classes of enzymes: E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. Research has linked dysregulation of the Ub/UBLs modification system to numerous diseases including cancer, immunological disorders, and neurodegeneration. Thus, the high substrate specificity provided by combinations of over 30 E2’s and over 600 E3’s makes these enzymes emerging drug targets.

In response to growing market demand, SignalChem has developed an extensive array of products encompassing ubiquitin proteins and active enzymes, Ub/UBL modifiers, and substrates in the ubiquitination, SUMOylation, ISGylation and NEDDylation processes. Using Promega’s AMP-Glo™ technology and an optimized assay protocol, we have identified and validated a variety of functional combinations of the enzyme components. With the established protocol, each enzyme in the catalytic cascade has been assessed for their activity towards the generation of free AMP. In addition, inhibition profiles of the ubiquitinating enzymes have been obtained using the assay system, further demonstrating their potential to be used in high-throughput screening to identify lead compounds for drug discovery and development programs.

SignalChem Product ListSC Master Cat #Product TypeApplicationsGenBank ID
CBL ProteinC272-381GUbiquitin ProteinsWestern BlotNM_005188
FANCL ProteinF289-30GUbiquitin ProteinsWestern BlotNM_018062
Parkin ProteinP215-30GUbiquitin ProteinsWestern BlotBC022014
PRPF19 ProteinP270-30GUbiquitin ProteinsWestern BlotNM_014502
RanGAP1 ProteinR298-31HUbiquitin ProteinsWestern BlotNM_002883
STUB1 (CHIP) ProteinC268-30HUbiquitin ProteinsWestern BlotNM_005861
SUMO1 (UBL1) ProteinS293-31HUbiquitin ProteinsWestern BlotNM_003352
SUMO2 ProteinS294-31HUbiquitin ProteinsWestern BlotBC008450
SUMO3 ProteinS295-31HUbiquitin ProteinsWestern BlotNM_006936
SYVN1 (HRD1) ProteinS284-31GUbiquitin ProteinsWestern BlotNM_172230
TRIM32 ProteinT291-30GUbiquitin ProteinsWestern BlotNM_012210
UBA2 (SAE2) ProteinU202-30GUbiquitin ProteinsWestern BlotNM_005499
UBA3 (UBE1C) ProteinU203-30GUbiquitin ProteinsWestern BlotBC022853
UBE2B ProteinU211-30HUbiquitin ProteinsWestern BlotNM_003337
UBE2F ProteinU220-30HUbiquitin ProteinsWestern BlotNM_080678
UBE2H ProteinU223-30HUbiquitin ProteinsWestern BlotNM_003344
UBE2J1 ProteinU225-30GUbiquitin ProteinsWestern BlotBC013973
UBE2L3 (UBCH7) ProteinU228-30HUbiquitin ProteinsWestern BlotNM_003347
UBE2R1 ProteinU234-30HUbiquitin ProteinsWestern BlotNM_004359
UBE2R2 (UBC3B) ProteinU235-30HUbiquitin ProteinsWestern BlotNM_017811
UBE2U ProteinU237-30GUbiquitin ProteinsWestern BlotNM_152489
UBE2V2 ProteinU239-30HUbiquitin ProteinsWestern BlotNM_003350
UBE2W (UBC16) ProteinU240-30GUbiquitin ProteinsWestern BlotBC010900
UBE2Z (USE1) ProteinU241-31HUbiquitin ProteinsWestern BlotNM_023079
Ubiquitin ProteinU06-54NUbiquitin ProteinsEnzyme Assay, Western BlotNM_018955
UBLE1A (SAE1) ProteinU208-30GUbiquitin ProteinsWestern BlotNM_005500
USP7 (C-Term) ProteinU570-31GUbiquitin ProteinsKinase Assay, Western Blot, Enzyme Function Tests, Enzyme AssayNM_003470
WWP1 ProteinW296-30GUbiquitin ProteinsWestern BlotNM_007013
BIRC3, ActiveB280-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_001165
BIRC7, ActiveB281-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotBC014475
HERC4, ActiveH265-381GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_015601
MGRN1, ActiveM287-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_015246
RanBP2, ActiveR230-381HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_006267
RNF34 (CARP), ActiveR296-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_025126
RNF34L (CARP2), ActiveR297-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_001017368
SAE1/UBA2 Complex, ActiveU208-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_005500 ,NM_005499
TRIM37, ActiveT292-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotBC036012
UBA1 (UBE1), ActiveU201-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003334
UBA6, ActiveU206-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotAL832458
UBA7(UBE1L), ActiveU207-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003335
UBE2A, ActiveU210-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003336
UBE2C, ActiveU212-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_007019
UBE2D1 (UBCH5A), ActiveU213-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003338
UBE2D2 (UBC4), ActiveU214-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_001093036
UBE2D3 (UBCH5C), ActiveU215-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003340
UBE2E1 (UBCH6), ActiveU217-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003341
UBE2E3 (UBCH9), ActiveU219-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_006357
UBE2G1 (UBC7), ActiveU221-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003342
UBE2I (UBC9), ActiveU224-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003345
UBE2K (UBC1), ActiveU227-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_005339
UBE2L6 (UBCH8), ActiveU229-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_004223
UBE2N (UBC13), ActiveU231-380HUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_003348
UBE2O, ActiveU232-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotBC022237
WWP2, ActiveW297-380GUbiquitin EnzymesUbiquitin Enzyme Assay, Western BlotNM_007014
AMSH, ActiveA565-380HDeubiquitinasesActivity Assay, Western BlotNM_006463
BAP1, ActiveB504-30HDeubiquitinasesActivity Assay, Western BlotNM_004656
ISG15, ProteinI245-31HDeubiquitinasesWestern BlotNM_005101
JosD2, ActiveI560-380HDeubiquitinasesActivity Assay, Western BlotNM_138334
MINDY1, ProteinM531-30GDeubiquitinasesWestern BlotNM_018379
NEDD8, ProteinN263-31HDeubiquitinasesWestern BlotNM_006156
OTUB1, ProteinO568-30HDeubiquitinasesWestern BlotNM_017670
OTUB2, ActiveO569-380HDeubiquitinasesActivity Assay, Western BlotNM_023112
OTUD6B, ProteinO576-30HDeubiquitinasesActivity Assay, Western BlotNM_016023
OTULIN, ProteinO585-30HDeubiquitinasesActivity Assay, Western BlotNM_138348
SENP1, ActiveS531-381HDeubiquitinasesActivity Assay, Western BlotNM_001267594
SENP2, ActiveS532-381HDeubiquitinasesActivity Assay, Western BlotNM_021627
SENP8, ActiveS538-380HDeubiquitinasesActivity Assay, Western BlotNM_145204
TNFAIP3 (A20p37), ActiveT563-381HDeubiquitinasesActivity Assay, Western BlotNM_006290
UCHL1, ActiveU522-380HDeubiquitinasesActivity Assay, Western BlotNM_004181
UCHL3, ActiveU524-380HDeubiquitinasesActivity Assay, Western BlotNM_006002
UCHL5, ActiveU526-380HDeubiquitinasesActivity Assay, Western BlotNM_001199261
USP11, ActiveU511-380GDeubiquitinasesActivity Assay, Western BlotNM_004651
USP14, ProteinU514-30GDeubiquitinasesWestern BlotNM_005151
USP15, ActiveU515-380GDeubiquitinasesActivity Assay, Western BlotNM_001252078
USP16, ActiveU516-381GDeubiquitinasesActivity Assay, Western BlotNM_006447
USP2, ActiveU502-381HDeubiquitinasesActivity Assay, Western BlotNM_004205
USP20, ActiveU520-381GDeubiquitinasesActivity Assay, Western BlotNM_006676
USP25, ProteinU525-31GDeubiquitinasesWestern BlotNM_013396
USP28, ActiveU528-381GDeubiquitinasesActivity Assay, Western BlotNM_020886
USP35, ActiveU535-381GDeubiquitinasesActivity Assay, Western BlotNM_020798
USP46, ProteinU546-30HDeubiquitinasesWestern BlotNM_022832
USP5, ActiveU505-380HDeubiquitinasesActivity Assay, Western BlotNM_003481
USP51, ProteinU551-31GDeubiquitinasesWestern BlotNM_201286
USP7 (N-term), ActiveU507-381HDeubiquitinasesActivity Assay, Western BlotNM_003470
USP8, ActiveU508-381HDeubiquitinasesActivity Assay, Western BlotNM_005154
YOD1, ProteinO572-30HDeubiquitinasesActivity Assay, Western BlotNM_018566

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