LUBIO COVID-19

Research Solutions for Coronavirus – Lubio Science

Available now: SARS-CoV-2 full-length trimeric spike protein

Full-length trimeric spike protein from SARS-CoV-2 coronavirus, the causative agent of COVID-19. Available as highly purified his-tagged trimeric protein in solution.

SARS-CoV-2 trimeric spike protein (wt) SARS-CoV-2 trimeric spike protein (D614G)
Conformation Wild type trimeric SARS-CoV-2 spike protein in prefusion conformation D614G variant trimeric SARS-CoV-2 spike protein in prefusion conformation
Modifications C-terminal Transmembrane region replaced with a trimerization domain and a polyhistidine tag. Two stabilizing proline mutations and scrambled S1/S2 furin cleavage site C-terminal Transmembrane region replaced with a trimerization domain and a polyhistidine tag. Two stabilizing proline mutations. Scrambled S1/S2 furin cleavage site. D614G mutation
Strain SARS-CoV-2 Betacoronavirus SARS-CoV-2 Betacoronavirus
Isolate (Seq ID) Wuhan-Hu-1 (GenBank: MN908947) Wuhan-Hu-1 (GenBank: MN908947) D614G variant
Expression System CHOExpressTM cells CHOExpressTM cells
Purity > 90 % as determined by SDS-PAGE > 90 % as determined by SDS-PAGE
Buffer 0.01M PBS, pH 7.4 , no preservatives 0.01M PBS, pH 7.4 , no preservatives
   Datasheet  
Cat-No. Item Size Price
LU2010-50UG Trimeric spike protein from SARS-CoV-2 50 ug £545
LU2011-50UG Trimeric spike protein from SARS-CoV-2, D614G variant 50 ug £545

References

  1. Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation (LINK TO PUBLICATION)
  2. Site-specific analysis of the SARS-CoV-2 glycan shield (LINK TO PUBLICATION)
  3. Structure-based design of prefusion-stabilized SARS-CoV-2 spikes (LINK TO PUBLICATION)
  4. Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures (LINK TO PUBLICATION)
  5. Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein (LINK TO PUBLICATION)
  6. Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike (LINK TO PUBLICATION)
  7. A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike (LINK TO PUBLICATION)

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