Founded in 2022, Allegrow’s vision is to decode complex cell surface signaling pathways to develop the next generation of cell therapy products that combine quality and cost-effectiveness.
Their technology, AimGel, consists of hydrogel based, chemically defined and animal-free artificial cells which have been engineered to mimic cell-like interactions and cell surface signaling responsible for various immune cell activation and expansion.
Self-degradable via Hydrolysis
Our AimGel artificial cells are hydrogel-based, meaning they can degrade naturally after expansion, eliminating the need for debeading steps. They are chemically defined and animal-free, ensuring greater peace of mind.
Higher T cell activation
AimGel artificial cells display activation signals on a fluid membrane, mimicking the immunological synapse and delivering outstanding efficiency and cell quality.
Lipid Membrane Coating
A fluid lipid coating mimicking the cell membrane enables cell-like interactions.
Hydrogel Core
A hydrogel core with variable size and softness to mimic the texture of real cells.
Surface Signals
Mix and match the required combinations of surface signals optimised for your cell type.
Resources
Step-by-step guide in using AimTconv for T cell expansion and activation.
T cell activation via anti-CD3 & anti-CD28 signals, along with anti-CD2 & anti-CD137, all presented on the AimGel artificial cell platform. AimGel’s fluid lipid membrane enables gentle and effective activation of T cells from isolated T cells and PBMC.
Quantity and Quality
Aim-Tconv outperforms traditional methods such as plastic beads and nanomatrix in both the amount of cells expanded and the viability of the cells expanded. You could even re-stimulate as Aim-Tconv’s signals are gentle.
Self-degradable via Hydrolysis
As hydrogel microparticles (HMPs), Aim-Tconv self-degrades via hydrolysis. So say goodbye to pesky debeading steps and hello to a streamlined workflow.
NK cell activation using signals presented on the AimGel artificial cell platform. AimGel’s fluid lipid membrane enables gentle and effective activation of NK cells from isolated NK cells or straight from PBMC.
Feeder-free expansion with feeder performance
Aim-NK matches the performance of feeder cells, while being synthetic and chemically-defined. Performance and consistency, you can have both.
When expanding NKs straight from PBMC with Aim-NK, get more than 90% NK cell fraction by day 21. That is more than 10,000X fold expansion of NK cells.
