Antibodies

GOLD™ and PLATINUM™  in vivo  Antibodies and Isotype Controls

Leinco Technologies provides industry-leading in vivo grade antibodies specifically designed for use in preclinical mouse model studies and other in vivo biological research applications. These high-performance antibodies are essential tools for exploring cell signaling pathways, immune response mechanisms, tumor microenvironments and therapeutic efficacy in animal models—particularly in murine systems commonly used for immunotherapy checkpoint blockade oncology, immunology and infectious disease research.

Our in vivo antibodies are rigorously purified to meet the highest quality standards, featuring:

• Ultra-low endotoxin levels
• No detectable protein aggregates or leachable Protein A
• Pathogen-free certification (via IDEXX Impact I PCR mouse pathogen profile)
• Highest Industry Purity Level Specifications

All antibodies are manufactured at our ISO 9001:2015 and ISO 13485:2016 certified facility in St. Louis, Missouri USA, ensuring consistency, reproducibility, and safety for animal injection and in vivo functional studies.

Figure 1. Efficacy of anti-PD-1 vs isotype
Both anti-PD-1 antibody clones (RMP1-14 and 29F.1A12) from Leinco Technologies were more efficacious than Vendor A’s products.

In vivo GOLD™ vs. in vivo PLATINUM™ Antibodies

Leinco offers two premium product lines tailored for in vivo use:

• In vivo GOLD™ Antibodies: High-purity reagents ideal for basic in vivo applications and mechanistic studies.
• In vivo PLATINUM™ Antibodies: Our top-tier antibodies, optimized for preclinical use, are verified to be pathogen-free, with low endotoxin levels and higher purity for sensitive in vivo research environments.

GOLD™ vs. PLATINUM™ in vivo Antibody Quality Standards

IDEXX IMPACT I (PCR-based) Mouse Pathogen Profile for Purified In vivo PLATINUM™ Grade Antibodies

Flexible Formats for Diverse Research Needs

Our in vivo antibodies are validated for use in:

• Mouse model studies
• Flow cytometry (FACS)
• In vivo blocking or depleting experiments
• Immunohistochemistry (IHC)
• Spatial biology and tissue imaging platforms

Available in standard pack sizes: 1 mg, 5 mg, 25 mg, 50 mg, and 100 mg, with custom concentrations, bulk quantities, and custom packaging available to support the specific needs of your in vivo research program.

mAbMods™ Chimeric Antibodies

Recombinant chimeric antibodies offer many advantages over those produced from traditional hybridoma technology. These include reduced immunogenicity, the ability to mute effector functions to avoid unwanted side effects, and decreased potential for genetic drift. The combination of these factors make recombinant antibodies an excellent choice for pre-clinical in vivo functional studies where prolonged and repeated administration of these antibodies is necessary.

mAbMods™ recombinant antibodies have been engineered to have identical antigen binding variable domains to those of the traditional clones from which they are derived, but the IgG constant regions have been engineered to be of mouse origin. This reduces immunogenic responses in the mouse, which can lead to adverse immunological reactions and gradual loss of activity.

Fc Muted mAbMods™ recombinant chimeric antibodies have engineered mutations (LALA-PG or D265A) in the Fc domain that reduce or eliminate the FcγR binding. This reduces Fc mediated effector functions such as Antibody-Dependent Cellular Cytotoxicity (ADCC), Antibody-Dependent Cellular Phagocytosis (ADCP), and Complement-Dependent Cytotoxicity that can lead to unwanted side effects.

IVD Products 

Buffers, Media, Substrates and IHC Reagents