microBrain

Consistent cultures of neurons and astrocytes co-matured from a single donor source

microHeart

Structured human cardiomyocytes in 2.5D and 3D formats

Complex human biology for complex questions

StemoniX’s microOrgan plates contain ready-to-use functional microtissues engineered from human induced pluripotent stem cells (iPSC). Designed to enable high-throughput human drug screening without the need for drugs to enter a human body, our microOrgans offer significant cost and time savings for our partners. 

Due to the structural and functional complexity of the Central Nervous System (CNS), the ability to obtain accurate and predictive in-vitro models for drug discovery and toxicology screening has been lacking. To fill this gap, StemoniX has developed the microBrain 3D platform: pre-plated neural spheroids composed of human iPSC-derived cortical neurons and astrocytes of uniform composition and size.

This presentation details how the Molecular Devices FLIPR Penta and ImageXpress Micro Confocal systems have been used to functionally and structurally characterize microBrain 3D spheroids from both healthy and disease sources.

Key highlights:

• Use of microBrain neuronal microspheroids

• Calcium oscillations in neural spheroids

• 3D image analysis of compound treated neural spheroids

• Multi-parametric evaluation of neurotoxicity effects