Consistent cultures of neurons and astrocytes co-matured from a single donor source
StemoniX provides products and services for drug discovery and development. We structure human iPSC-derived cells into physiologically relevant microtissues with accelerated cell maturity that mimic the native organ tissue. Predictive, accurate, and consistent, our in vitro human cell-based products enable scientists to quickly and economically conduct research with improved outcomes in a simplified workflow.
Complex human biology for complex questions
StemoniX’s microOrgan plates contain ready-to-use functional microtissues engineered from human induced pluripotent stem cells (iPSC). Designed to enable high-throughput human drug screening without the need for drugs to enter a human body, our microOrgans offer significant cost and time savings for our partners.
Due to the structural and functional complexity of the Central Nervous System (CNS), the ability to obtain accurate and predictive in-vitro models for drug discovery and toxicology screening has been lacking. To fill this gap, StemoniX has developed the microBrain 3D platform: pre-plated neural spheroids composed of human iPSC-derived cortical neurons and astrocytes of uniform composition and size.
This presentation details how the Molecular Devices FLIPR Penta and ImageXpress Micro Confocal systems have been used to functionally and structurally characterize microBrain 3D spheroids from both healthy and disease sources.
Use of microBrain neuronal microspheroids
Calcium oscillations in neural spheroids
3D image analysis of compound treated neural spheroids
Multi-parametric evaluation of neurotoxicity effects
BIO2020 Digital Panel Discussion
StemoniX CEO, Ping Yeh, participated in a panel on
Organs on a Chip and AI: Realizing Potential Efficiencies in Drug Discovery.
This panel explored how highly scalable iPSC-based technologies could deliver significant cost and time savings to the pharmaceutical industry, reduce animal testing, and potentially lead to safer, more effective human clinical trials.
StemoniX Neural Progenitor Cells used in microBrain StemoniX human iPSC-Derived Neural Progenitor Cells (NPCs) are a homogeneous, self-renewing and multipotent Read More…
Winner of CONNECT’s Most Innovative Product Award for Life Science Diagnostics & Research Tools A Structured Environment for Cell Performance Read More…
Structure Leads to Improved Cell-Based Assay Outcomes A Structured Environment for Cell Performance StemoniX® microBrain® 2D Assay Ready, pre-plated product is Read More…
Structure Leads to Improved Cell-Based Assay Outcomes Neural Network Structure and Cell Maturity The neural network structure of microBrain cortical Read More…
Stemonix’s microOrgan plates contain ready-to-use functional microtissues engineered from human induced pluripotent stem cells (iPSC). Designed to enable high throughput Read More…