ANPEP/CD13 (ANPEP, APN, CD13, PEPN, Aminopeptidase N, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD_antigen=CD13) (Azide free) (HRP)

Catalogue Number: 030775-HRP-USB

Manufacturer:	United States Biological
Preservative:	Azide-free
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	alanyl (membrane) aminopeptidase\|aminopeptidase M\|aminopeptidase N\|AP-M\|APN\|AP-N\|CD13\|GP150\|hAPN\|LAP1\|membrane alanyl aminopeptidase\|microsomal aminopeptidase\|myeloid plasma membrane glycoprotein CD13\|P150\|PEPN
Shipping Condition:	Blue Ice
Unit(s):	200 ul
Host name:	Mouse
Clone:	505CT12.1.2
Isotype:	IgG2a
Immunogen:	KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 156-184 of human ANPEP/CD13.
Application:	ELISA, WB

Overview
Datasheets

Description

Description: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene ID

290

Gene Name

ANPEP

Uniprot ID

P15144

Accession Number

NP_001141.2

Specificity

Human

Purification

Protein G purified

Antibody Clonality

Monoclonal

030775-HRP Datasheet

Price

£863.00

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