NLRP3/NALP3 (NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein) (Biotin)
Catalogue Number: 045088-BIOTIN-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Mouse |
| Clone: | Cryo-2 |
| Isotype: | IgG2b |
| Immunogen: | Recombinant protein corresponding to mouse NLRP3/NALP3 (pyrin domain/aa1-93). |
| Application: | ICC, IP, ChIP, WB, IHC |
Description
Description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
Additional Text
Purification
Protein G purified
Antibody Clonality
Monoclonal
SUPPORT
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PRODUCT
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DELIVERY
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