TRAIL-R2 (ATTO 488) (TRAIL Receptor 2, DR5, KILLER, TNFRSF10B, CD262)
Catalogue Number: 045354-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 0.02% sodium azide. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 Tests |
| Host name: | Mouse |
| Clone: | HS201 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human TRAIL-R2 (DR5). |
| Application: | FC, ICC |
Description
Description: TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene Name
TNFRSF10B
Uniprot ID
O14763
Gene ID
8795
Specificity
Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
Antibody Clonality
Monoclonal
045354 Datasheet
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