PSD-95 (Palmitoylated)

Catalogue Number: 048732-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Human
Clone:	PF11 (recomb)
Isotype:	IgG2
Immunogen:	Palmitoylated PSD-95.
Application:	ICC, IHC

Overview
Datasheets

Description

Description: PSD-95 is a member of proteins located at a specialized postsynaptic membrane region, called the postsynaptic density (PSD). PSD-95 is the most abundant scaffold protein specifically enriched in the PSD. It contains three PDZ domains, an SH3 domain and a guanylate kinase (GuK)-like domain. Through its PDZ domains, PSD-95 assembles various synaptic components at the PSD including intracellular signaling molecules (e.g. SynGAP and kalirin-7), ion channels (e.g. stargazin/AMPA receptors [AMPARs] and NMDA receptors) and cell adhesion molecules (e.g. neuroligin). PSD-95 plays a primary role in synaptic development and maturation and is regulated by palmitoylation at its N-terminal cysteine residues leading to its postsynaptic targeting. Palmitoylation of PSD-95 is triggered by DHHC2, a plasma membrane-inserted palmitoylating enzyme. Palmitoylated PSD-95 is almost exclusively localized at excitatory synapses in neurons. 048732 is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the human lgG2 Fc domain. Produced without the use of animals. Purified from HEK 293 cell culture supernatant.

Additional Text

Antibody Clonality

Monoclonal

Purification

Purified by Protein A affinity chromatography from animal free supernatant. ≥95% (SDS-PAGE)

048732 Datasheet

Price

£586.00

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