Botulinum Neurotoxin Type D Heavy Chain (C. botulinum BoNT-D Heavy Chain, BoNTD Heavy Chain, BoNT-D Heavy Chain)
Catalogue Number: 052019-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 24G3 |
| Isotype: | IgG2b |
| Immunogen: | Recombinant protein corresponding to Asn862-Glu1276 from C. botulinum Neurotoxin Type D Heavy Chain, expressed in E. coli |
| Application: | WB |
Description
Description: BoNT-D (Botulinum neurotoxin serotype D) is produced by Clostridium botulinum and inhibits acetylcholine release from neuromuscular junctions. Notably, BoNT-D is not toxic to human cells. The 1276 amino acid (aa) BoNT-D precursor is cleaved to generate a disulfide-linked dimer of the 50-55kD light chain peptidase and the 100kD heavy chain. The heavy chain contains receptor binding and pore forming domains. The light chain translocates through this pore to the target cell cytosol where it cleaves synaptobrevin, thus blocking synaptic vesicle fusion with the presynaptic membrane. Within aa862-1276 of the heavy chain, BoNT-D shares 31%, 33%, and 41% aa sequence identity with BoNT-A, -B, and -C1 heavy chains, respectively.
Additional Text
Purification
Protein A purified
Antibody Clonality
Monoclonal
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