Interferon gamma (IFN-gamma)
Catalogue Number: 052077-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 24I2 |
| Isotype: | IgG2a |
| Immunogen: | Recombinant protein corresponding to Ser21-Lys166 from porcine IFN gamma, expressed in E. coli. |
| Application: | ELISA |
Description
Description: Interferon-gamma (IFN-gamma), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Mature porcine IFN-gamma exists as a noncovalently linked homodimer of 20-25kD variably glycosylated subunits. It shares 72%-79% amino acid sequence identity with bovine, canine, equine, and feline IFN-gamma and 41%-57% with cotton rat, human, mouse, rat, and rhesus IFN-gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, anti-proliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.
Additional Text
Gene Name
IFNG
UniProt ID
P17803
Gene ID
396991
Purification
Protein A purified
Antibody Clonality
Monoclonal
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