Stat5, phosphorylated (Tyr694) (Signal Transducer and Activator of Transcription 5A, Stat5A)

Catalogue Number: 052083-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	M148
Isotype:	IgG1
Immunogen:	Synthetic peptide corresponding to amino acid residues around tyrosine 694 of human Stat5A, coupled to KLH. This peptide sequence is identical to tyrosine 699 in human Stat5B, and has high homology to the conserved tyrosine site in rat and mouse Stat5A/B.
Application:	ICC, WB

Overview

Description

Description: The stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone, and prolactin. Phosphorylation at Tyr-694 is required for Stat5A activation. Stat5 has been found to be constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility. Both Stat5A (Tyr-694) and Stat5B (Tyr-699) are independently regulated and activated in various cell types. For instance, both isoforms are activated in response to IFNα in B cells, but only Stat5A is phosphorylated in response to IFNα in HeLa cells.

Additional Text

Gene Name

STAT5A

Gene ID

6776

Uniprot ID

P42229

Modification

Phosphorylated, Tyr694

Purification

Protein A purified

Antibody Clonality

Monoclonal

Price

£618.00

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