Stat3, NT (Signal Transducer and Activator of Transcription 3)
Catalogue Number: 052085-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | M263 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein corresponding to amino acid residues in the N-terminal region of human Stat3. This sequence has high homology to the conserved regions in rat and mouse Stat3 α and β. |
| Application: | IP, WB |
Description
Description: The stat proteins (Stat1-6) function both as cytoplasmic signal transducers and as activators of transcription in response to cytokines and growth factor receptors. Stat3 is expressed as two variants, Stat3α (86kD) and Stat3b (79kD) that can differ in expression and activity depending on cell type, activation pathway, and cell maturation stage. Both are activated by phosphorylation at Tyr-705, which induces dimerization, nuclear translocation and DNA binding. Stat3α (86kD) transcriptional activation may be regulated by phosphorylation at Ser-727 through the MAPK pathway, while Stat3β lacks this serine site.
Additional Text
Gene Name
STAT3
Gene ID
6774
Uniprot ID
P40763
Purification
Protein A purified
Antibody Clonality
Monoclonal
SUPPORT
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PRODUCT
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DELIVERY
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