KI67 (MKI67)
Catalogue Number: 052158-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 500 ul |
| Host name: | Mouse |
| Clone: | 6b4 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant construct containing the 2nd, 3rd and 4th Ki67 repeats of the human sequence (aa1111-1490), expressed in E. coli. |
| Application: | ICC, IF, WB |
Description
Description: The Ki67 proteins were first discovered in an attempt to generate cancer specific monoclonal antibodies. A monoclonal antibody which bound to structures in the nuclei of dividing but not quiescent cells was produced and shown to bind two very large proteins of molecular weight 345kD and 395kD. The two proteins were derived from alternate transcripts of a single gene. The presence of Ki67 proteins, detected with an appropriate antibody, is an indicator of cell proliferation and the level of Ki67 expression is one of the most reliable biomarkers of proliferative status of cancer cells. Recent studies show that Ki67 coats dividing chromosomes and ensures that each one enters the appropriate daughter cell.
Additional Text
Gene Name
MKI67
Uniprot ID
P46013
Gene ID
4288
Purification
Protein G purified
Antibody Clonality
Monoclonal
SUPPORT
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PRODUCT
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DELIVERY
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