SCARB1 (Scavenger Receptor Class B Member 1, SRB1, SR-BI, CD36, CD36L1)

Catalogue Number: 052198-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	5B8.2
Isotype:	IgM, kappa
Immunogen:	KLH-conjugated linear peptide corresponding to the extracellular domain of human SCARB1.
Application:	WB, IHC

Overview

Description

Description: Scavenger receptor class B member 1 (SCARB1), or CD36L1, is the membrane bound cell surface receptor for high density lipoprotein (HDL) as well as a number of related compounds such as phospholipids, cholesterol ester, and phosphatidylserine and apoptotic cells (via their expression of phosphatidylserine on their extracellular surfaces). SCARB1 is also the receptor for Hepatitis C virus glycoprotein E2 and it facilitates the attachment and entry of HCV. SCARB1 plays a critical role in cholesterol homeostasis and mediates cholesterol transfer to and from the HDL protein carriers, a process known as reverse cholesterol transport. It is highly expressed in tissues that require free cholesterol such as the liver and steroidogenic tissues (adrenals, testis, ovary). SCARB1 expression has also been associated with particular cancers including chronic myeloid leukemia (CML), breast cancer, bladder carcinoma, and prostate cancer.

Additional Text

Gene Name

SCARB1

Gene ID

949

Uniprot ID

Q8WTV0

Purification

Purified

Accession Number

NP_005496

Antibody Clonality

Monoclonal

Price

£819.00

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