p53 (BCC7, TRP53, TP53, LFS1, Cellular Tumor Antigen p53) (Biotin)
Catalogue Number: 052207-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | BP53-12 |
| Isotype: | IgG2a |
| Immunogen: | Bacterially expressed full-length human wild-type p53 |
| Application: | ELISA, FC, ICC, IP, WB, IHC |
Description
Description: The tumor suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerization domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.
Additional Text
Gene Name
TP53
Gene ID
7157
Uniprot ID
P04637
Accession Number
NM_000546
Purification
Purified
Antibody Clonality
Monoclonal
SUPPORT
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