S-100 Protein (Calcium Binding Protein A1/B1)
Catalogue Number: 052314-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 15E2E2 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Purified bovine S-100 protein. |
| Application: | IP, WB, IHC |
Description
Description: S-100 protein is a member of the EF-hand calcium-binding protein superfamily that is widely distributed and conserved in the central nervous system of vertebrates. The protein exists in both heterodimeric and homodimeric forms. The two subunits of S-100 protein are the products of separate genes that are differentially expressed by various cells. The beta subunit is present in all S-100 positive cells and tumors. In contrast, the alpha subunit is detectable only in heart, skeletal muscle and brain. In addition to its calcium binding properties, S-100 protein has a high-affinity binding site for zinc and is involved in the regulation of protein phosphorylation in the brain. The protein apparently plays a role in cell differentiation and growth, cytoskeletal structure and function, and has been implicated in neuropathological diseases.
Additional Text
Gene ID
6271
Gene Name
S100A1
Uniprot ID
P23297
Accession Number
NM_006271.1
Purification
Protein A purified
Antibody Clonality
Monoclonal
SUPPORT
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DELIVERY
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