Monoclonal antibody to DR4 (Clone: ABM1B11 )
Catalogue Number: 10-1002-ABO
10-1002 Image
10-1002 Image
10-1002 Image
Fig.1: Intracellular FLOW analysis of Jurkat cells using 0.5 ug of DR4 antibody (Clone: ABM1B11). Isotype contol mouse IgG1 (ABEOMICS) was used. Goat Anti-mouse PE was used as secondary antibody.
10-1002 Image
Fig.2: Expression analysis of DR-4. Anti-DR4 antibody (Clone: ABM1B11) was tested at 2 µg/ml on K562 lysate.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | TNFRSF10A||APO2||DR4||TRAILR1 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Mouse |
| Clone: | ABM1B11 |
| Isotype: | IgG1, kappa |
| Immunogen: | A partial length recombinant human DR4 protein (amino acids 2-203 was used as an immunogen for this antibody. |
| Application: | FACS, WB |
Description
Description: Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediates oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.
Additional Text
Gene Name
TNFRSF10A
Gene ID
8797
Purification
Protein G purified
Uniprot ID
O00220
Antibody Clonality
Monoclonal
Application Notes
Western blot analysis: 2-4 µg/ml, FACS analysis- 0.5-1 µg/10^6 Cells
10-1002 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations