Monoclonal Antibody to Dc-Sign/CD 209 (Clone: ABM47B7)
Catalogue Number: 10-10020-ABO
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10-10020 Image
10-10020 Image
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Fig-2: Expression analysis of Dc-Sign. Anti-Dc-Sign antibody (Clone: ABM47B7) was tested at 0.1 µg/ml on human Liver lysate.
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Fig-3: Cell Surface FLOW analysis of Dc-Sign antibody (10-10020) in 293HEK-Dc-sign stable cell line using 0.5 µg/ 10^6 cells. Green represents isotype control, red represents anti- Dc-Sign antibody. Goat anti-mouse PE conjugates was used as secondary antibody.
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Fig-1: Expression analysis of Dc-Sign. Anti-Dc-Sign antibody (Clone: ABM47B7) was tested at 0.1 µg/ml on partial length recombinant protein.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | CD209||CLEC4L |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Mouse |
| Clone: | ABM47B7 |
| Isotype: | IgG2b, kappa |
| Immunogen: | A recombinant protein fragment of DC-Sign protein was used as the immunogen for this antibody. |
| Application: | FACS, WB |
Description
Description: Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a tetrameric C-type (calcium-dependent) lectin that binds, through its C-terminal carbohydrate recognition domain, high mannose N-linked glycans present on the surface of several viral glycoproteins such as human immunodeficiency virus (HIV) gp120 and hepatitis C virus (HCV) E2. It facilitates DC-specific delivery of Ag. This is accomplished by conjugating Ag to receptor-specific Ab or carbohydrate ligands that bind to its carbohydrate recognition domain. In humans, DC-SIGN expression is restricted to DCs and certain types of macrophages. DC-SIGN is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens, including viruses, bacteria, fungi, and parasites. After binding, these pathogens are internalized and pathogen-derived antigens are presented via MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. DC-SIGN represents a promising CLR for targeted vaccine delivery.
Additional Text
Gene Name
CD209
Purification
Protein G purified
Uniprot ID
Q9NNX6
Gene ID
30835
Antibody Clonality
Monoclonal
Application Notes
Western blot analysis: 0.1-0.5 µg/ml; FACS: 0.5-1 µg/10^6 Cells Reference for expression of Dc-Sign: Wai K. Lai, Phoebe J. Sun, Jie Zhang, Adam Jennings, Patricia F. Lalor, Stefan Hubscher,Jane A. McKeating,and David H. Adams. Expression of DC-SIGN and DC-SIGNR on Human Sinusoidal Endothelium Am J Pathol. 2006 Jul; 169(1): 200-208.doi: 10.2353/ajpath.2006.051191
10-10020 Datasheet
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