Monoclonal antibody to MyD88 (Clone: ABM2H20) FITC Conjugated
Catalogue Number: 10-3012-F-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Mouse |
| Clone: | ABM2H20 |
| Isotype: | IgG1, kappa |
| Immunogen: | A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody. |
| Application: | FACS |
Description
Description: MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.
Additional Text
Gene Name
MYD88
Gene ID
4615
Purification
Protein G purified
Uniprot ID
Q99836
Antibody Clonality
Monoclonal
Application Notes
FACS Analysis: 0.5-1 µg/ml
10-3012-F Datasheet
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