Monoclonal Antibody to NALP3 (Clone: ABM2D48)

Catalogue Number: 10-3018-ABO

Manufacturer:	Abeomics
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	NLRP3\|\|C1orf7\|\|CIAS1\|\|NALP3\|\|PYPAF1
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	100 ug, 25 ug
Host name:	Mouse
Clone:	ABM2D48
Isotype:	IgG2b, kappa
Immunogen:	A partial length recombinant NALP3 protein (amino acids 150-385) was used as the immunogen for this antibody.
Application:	WB, IHC

Overview
Datasheets

Description

Description: NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.

Additional Text

Gene Name

NLRP3

Gene ID

114548

Purification

Protein G purified

Uniprot ID

Q96P20

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 6-8 µg/ml, Immunohistochemical analysis: 5 µg/ml

10-3018 Datasheet

Price

£260.00

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