Monoclonal Antibody to MBD1 (Clone: ABM15H2) FITC Conjugated
Catalogue Number: 10-7007-F-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | MBD1||CXXC3||PCM1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | ABM15H2 |
| Isotype: | IgG1, kappa |
| Immunogen: | A partial length recombinant MBD1 protein (amino acids 291-586) was used as the immunogen for this antibody. |
| Application: | FACS |
Description
Description: MBD1 (Methyl-CpG-Binding Domain Protein 1) protein is a primary candidate for the readout of DNA methylation as it recruits chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. This protein, a member of a transcriptional repressor family MBD, is predominantly expressed in neurons. MBD protein binding requires both functional MBD domains and methyl-CpGs; however, some MBD proteins also bind unmethylated DNA and active regulatory regions via alternative regulatory domains or interaction with the NuRD/Mi-2 (Nucleosome Remodeling Deacetylase) complex members. The CXXC3 domain of MBD1 makes it a unique member of the MBD family due to its affinity to unmethylated DNA. MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex. It also plays an important role in disease progression, contributes to the drug resistance of PC cells; however, the mechanism underlying the drug resistance endowed by MBD1 remains unknown.
Additional Text
Gene Name
MBD1
Gene ID
4152
Purification
Protein G purified
Uniprot ID
Q9UIS9
Antibody Clonality
Monoclonal
Application Notes
FACS: 0.5-2 µg/10^6 cells
10-7007-F Datasheet
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