Anti-Human Osteopontin (10A16) Mouse IgG MoAb

Catalogue Number: 10011-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 200 ug
Host name:
Clone: 10A16
Isotype: IgG1
Immunogen: Synthetic peptide of a part of human osteopontin

Description

Description: Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other fluids and tissues including milk, urine, activated T cells, smooth muscle cells, kidney and some tumor cells. OPN contains an Arg-Gly-Asp (RGD) amino acid sequence. This motif is present in fibronectin, vitronectin and a variety of other extra-cellular proteins that bind members of the integrin family of cell surface receptors such as αvβ3. OPN was also identified as a ligand for CD44, which levels correlate with aggressiveness of lymphoid tumors and invasiveness of bladder carcinoma. Its interaction does not require RGD motif of OPN. In OPN knockout mice, it has been reported that a significantly decreased level of debridement was shown. Although the distribution and expression pattern of OPN in the human body have suggested the multiple function of OPN, its function under different situations remain obscure. And it is reported the N-terminal OPN fragment cleaved by thrombin (OPN N-Half) binds to α4 or α9 integrin, and the relation with many inflammatory disease is suggested.

Additional Text

Specificity

Reacts with human osteopontin. Does not cross-react with mouse or rat.