Catalogue Number: 10078-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Type:||Monoclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Unit(s):||100 ug, 10 ug|
|Immunogen:||Rat Hepatic Sinusoidal Endothelial Cells|
Description: Among the vascular endothelial cells, hepatic sinusoidal endothelial (HSE) cells are morphologically unique because they have open fenestrations in their cytoplasm and lack basal lamina. This unique structure is assumed to facilitate the exchange and transport of various substances between blood and hepatocytes through the space of Disse. It has been suggested that the formation of this structure is regulated by hepatocyte-related soluble factors or by the extracellular matrix. The antibody was observed no cross-reactivity with other types of endothelial cells or non-endothelial cells. By immunoelectron microscopy, the antigen recognized by the antibody was localized to the membrane surface of HSE. Immunoblot analysis revealed that the antibody recognized a single 45 kDa band. The antibody may be a useful marker to study the role of HSE in various pathophysiological conditions of the liver.