Anti-Human Lag (Langerhans Cells), (4D12) Mouse IgG MoAb

Catalogue Number: 10101-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 200 ug
Host name:
Clone: 4D12
Isotype: IgG1
Immunogen: Human Langerhans cells

Description

Description: Langerhans cells (LC) were reported to function as the antigen-presenting cells in the skin. They express immune response gene-associated antigens on their cell membranes. These cells seem to mediate contact sensitivity in vivo and the antigen-specific response of T lymphocytes in vitro. Langerhans cells also have surface receptors for the Fc portion of immunoglobulin G (IgG) and for the third component of complement, C3. They originate from the bone marrow, but details about the precursors of LC are not known. This antibody reacts specifically to human LC. The protein recognized by this antibody was mainly in the membranes of Birbeck granules and related structures.

Additional Text

Specificity

Reacts with membrane protein of Birbeck granules