iFluor® 560 Anti-human CD11b Antibody *HI11b*
Catalogue Number: 101110A0-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | HI11b |
| Isotype: | IgG2b |
| Immunogen: | |
| Application: | FC, IF |
Description
Description: HI11b is an anti-human monoclonal antibody that recognizes the CD11b antigen. CD11b (sometimes referred to as Integrin αM chain, C3biR, CR3A or CR3) is a 165 - 170 kD glycoprotein that is expressed on the surface of cells such as B cells, granulocytes, NK cells, macrophages and dendritic cells. CD11b is involved with important cellular pathways, in particular, the cytokine-mediated signaling pathway, toll-like receptor 4 signaling pathway and apoptotic signaling pathway. Additionally, in many organisms, it is a promoter of superoxide anion generation, positively regulates microglial cell mediated cytotoxicity and is a positive regulator of prostaglandin-E synthase activity. CD11b has been associated with critical biological processes like cell adhesion, specifically cell-cell adhesion via plasma-membrane adhesion molecules, and is associated with a variety of biologically interesting macromolecules/ligands, for example, Factor X, iC3b and ICAM-1. CD11b is a very popular antibody target, with over 45000 publications in the last decade. CD11b has been widely used in innate immunity, neuroscience cell markers and cell biology research, often serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to iFluor® 560 (ex/em = 560/571 nm). It is compatible with the 561 nm laser and 586/20 nm bandpass filter (for example, as in the Agilent Technologies NovoCyte Quanteon).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
101110A0 Protocol
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations