Catalogue Number: 10201-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Physical state:||Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3|
|Type:||Monoclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Unit(s):||100 ug, 10 ug|
|Immunogen:||Human MDMX Recombinant protein|
Description: The p53 tumor suppressor protein is stabilized in response to cellular stress, resulting in activation of genes responsible for either cell cycle arrest or apoptosis. The cellular pathway for releasing normal cells from p53- dependent cell cycle arrest involves the MDM2 protein. Recently, a p53- binding protein with homology to MDM2 was identified and called MDMX. Like MDM2, MDMX is able to bind p53 and inhibit p53 transactivation. It is proposed that the MDMX protein may function to maintain a nuclear pool of p53 protein in undamaged cells.