Anti-Human c-Kit (12A8) Mouse IgG MoAb (Frozen)

Catalogue Number: 10349F-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Frozen product in PBS ( Non-containing BSA and NaN3, sterilized)
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Dry Ice
Storage Condition:2-8°C
Unit(s): 100 ug
Host name:
Clone: 12A8
Isotype: IgG1
Immunogen: Recombinant protein of extracellular domain of human c-Kit

Description

Description: The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor, and its ligand for c-Kit receptor has been identified as the stem cell factor (SCF). Recent experimental studies have shown that c-Kit plays a key role in the development of a component of the pacemaker system that is required for generation of autonomic gut motility. These studies further suggest that interaction of the c-Kit and SCF is essential for development of enteric nervous system. Recently, it is reported that the c-Kit may be an important marker for gastrointestinal stromal tumors (GISTs) which may originate from the interstitial cells of Cajal (ICCs).

Additional Text

Specificity

Confirmed by western blotting with SY cell.