PE/XFD700 Anti-non-human primates/ human CD35 Antibody *E11*
Catalogue Number: 103501Q1-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | E11 |
| Isotype: | IgG1 |
| Immunogen: |
Description
Description: E11 is an anti-non-human primates/ human monoclonal antibody that recognizes the CD35 antigen. CD35 (alternatively called Complement receptor type 1) is a single-pass type I membrane protein that is found on the surface of cells such as erythrocytes. CD35 plays a role in key cellular pathways, for example, the negative regulation of complement activation, alternative pathway and complement activation, classical pathway. Moreover, in certain organisms, it represses serine-type endopeptidase activity, plays a role in the downregulation of complement activation, alternative pathway and is involved in the positive regulation of serine-type endopeptidase activity. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as ic3, c4b, c3b and ic4. CD35 is a fairly uncommon antibody target, with a little more than 1800 publications in the last decade. Even still, CD35 has been widely used in immunology, cell biology and neuroinflammation research, commonly serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to PE/XFD700 (ex/em = 566/721 nm). XFD700 is manufactured by AAT Bioquest, and it has the same chemical structure of Alexa Fluor® 700 (Alexa Fluor® is the trademark of ThermoFisher). It is compatible with the 561 nm laser and 702/85 nm bandpass filter (for example, as in the Luminex Amnis FlowSight).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
103501Q1 MSDS
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