Anti-Human PDGFRβ (22B1) Mouse IgG MoAb (Frozen)

Catalogue Number: 10351F-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Frozen product in PBS ( Non-containing BSA and NaN3, sterilized) 
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Dry Ice
Storage Condition:2-8°C
Unit(s): 100 ug
Host name:
Clone: 22B1
Isotype: IgG1
Immunogen: Recombinant protein of extracellular domain of human PDGFRβ


Description: PDGF, a ligand of PDGFR, has 4 isofoms, A-, B-, C- and D-chains, and forms hetero and/or homo dimers, PDGF-AA, -AB, -BB, -CC, -DD. On the other hand, PDGFR has 2 isoforms, α- and β-chains and forms hetero and/or homo dimers, PDGFR-αα, -αβ and -ββ. PDGF-A and PDGF-C binds specifically to PDGFR-α, PDGF-B binds to PDGFR-α and PDGFR-β, and PDGF-D binds specifically to PDGFR-β. In other words, PDGF-AA and PDGF-CC can activate only PDGF-αα, while PDGF-AB can activate PDGFR-αα and PDGFR-αβ, and PDGF-BB can activate PDGFR-αα, -αβ and -ββ. While, PDGF-DD has been reported to be able to activate PDGFR-αβ as well as PDGFR -ββ. When the receptor is dimerized, tyrosine kinase activity in the intracellular region increases and auto-phosphorylation of the tyrosine residue takes place.

Additional Text


Confirmed by western blotting with TIG-7 cell.