Anti-Human Tie-1 (9C1) Mouse IgG MoAb

Catalogue Number: 10353-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 10 ug
Host name:
Clone: 9C1
Isotype: IgG2a
Immunogen: Recombinant protein of extracellular domain of human Tie-1


Description: TIE is a new receptor-type tyrosine kinase that was cloned from K562, a chronic myelocytic leukemia cell line. Its molecular weight is 117 kDa and its structure begins with an immunoglobulin-like domain from the extracellular N terminal, continues to 3 EGF-like domains, another immunoglobulin-like domain, 3 fibronectin III-like domains, a membrane-penetrating domain, 2 tyrosine kinase domains and a C-terminal domain. It has been reported that Tek molecules with a high homology (about 80%) have been cloned from the kinase domains. These molecules are believed to make up a Tie family. Tie-2 and a receptor type tyrosine kinase Tie-1 that is expressed specifically in endothelial cells are included in this Tie family. Among the Tie-1 gene knockout mice, a vasculature is formed in a homozygote (-/-) but the mouse is likely to succumb to pulmonary edema. Thus it has been reported that the signal via Tie-1 is important in maintaining the vascular structure.

Additional Text


Confirmed by western blotting with HEL (leukemia) cell.


Find out about delivery


outstanding technical support


we offer a full product guarantee


we offer free delivery to UK universities and non profit organisations