Anti-Human NP95 (mt40) Mouse IgG MoAb
Catalogue Number: 10371-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 10 ug |
| Host name: | Mouse |
| Clone: | mt40 |
| Isotype: | IgG, IgG1 |
| Immunogen: | Purified human NP95 protein |
| Application: | WB |
Description
Description: Np95 has been originally found as a tumor-specific nuclear antigen of 95kDa in mice. Experiments using B10 strains showed that Np95 is enriched in precancerous cells and is abnormally expressed throughout cell cycle in radiation-induced lymphomatoid cells. Recent attention is put on the epigenetic role of Np95, which mediates the interplay between DNA methylase and hemi-methylated sites to maintain DNA methylation patterns at replication forks. This antibody is available for detection of the human nucleoprotein NP95 (also known as UHRF1), whose function is dependent on S-phase in non-neoplastic cells but could be modified with abberant cell cycle during tumorigenesis.
Additional Text
Purification
Protein A purified
Antibody Clonality
Monoclonal
10371 Datasheet
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