Anti-Mouse ALK (mAb 16-39) Rat IgG MoAb 10373
Catalogue Number: 10373-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug |
| Host name: | Rat |
| Clone: | |
| Isotype: | IgG, IgG2b |
| Immunogen: | Recombinant protein of the extracellular domain of mouse ALK |
| Application: | IP, WB |
Description
Description: Anaplastic lymphoma kinase (ALK, anaplastic lymphoma kinase) is a receptor type tyrosine kinase, and is found to be expressed in the central and peripheral nervous system at late embryonic stage. Motegi et al. developed an agonist monoclonal antibody against the extracellular domain of ALK. This monoclonal antibody (clone mAb16-39) elicits tyrosine phosphorylation of ALK in human neuroblastoma (SK-N-SH) cells. And it also induces further phosphorylation of signal transfer molecules like IRD-1 (insulin receptor substrate-1) which interact with ALK. Moreover, continuous incubation with this antibody induced the cell-growth and neurite outgrowth of SK-N-SH cells.
Additional Text
Purification
Protein G purified
Antibody Clonality
Monoclonal
10373 Datasheet
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