Anti-Human IDH1 R132H (HMab-1) Mouse IgG MoAb

Catalogue Number: 10389-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 10 ug
Host name:
Clone: HMab-1
Isotype: IgG1
Immunogen: Synthetic peptide of a part of human IDH1 R132H

Description

Description: Specific mutations in the isocitrate dehydrogenase 1 gene IDH1 have been found in several brain tumors including astrocytoma, oligodendroglioma and glioblastoma multiforme, with mutations found in nearly all cases of secondary glioblastomas, but rarely in primary high-grade glioblastoma multiforme. Individuals whose tumor had an IDH1 mutation had longer survival. Another report shows that mutations of IDH2 and IDH1 were found in up to 20 % of cytogenetically normal acute myeloid leukemia (AML). These mutations are known to produce 2-hydroxyglutarate (2HG) from alpha-ketoglutarate, and it is suggested that high 2HG levels may trigger epigenetic changes within the cells and the development of cancer. The IDH1 mutations are remarkably specific to a single codon in the conserved and functionally important Arginine 132 residue (R132) in IDH1. This antibody is developed as a monoclonal antibody which can specifically detect R132H mutation of IDH.

Additional Text

Specificity

React with human IDH1-R132H. Not react with human IDH1 wild-type or the other IDH1 mutations.

Price
280.00


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