Anti-Human IDH1 R132S (SMab-1) Mouse IgG MoAb 10391
Catalogue Number: 10391-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 10 ug |
| Host name: | Mouse |
| Clone: | SMab-1 |
| Isotype: | IgG, IgG1 |
| Immunogen: | Synthetic peptide of a part of human IDH1 R132S |
| Application: | WB, IHC |
Description
Description: Specific mutations in the isocitrate dehydrogenase 1 gene IDH1 have been found in several brain tumors including astrocytoma, oligodendroglioma and glioblastoma multiforme, with mutations found in nearly all cases of secondary glioblastomas, but rarely in primary high-grade glioblastoma multiforme. Individuals whose tumor had an IDH1 mutation had longer survival. Another report shows that mutations of IDH2 and IDH1 were found in up to 20 % of cytogenetically normal acute myeloid leukemia (AML). These mutations are known to produce 2-hydroxyglutarate (2HG) from alpha-ketoglutarate, and it is suggested that high 2HG levels may trigger epigenetic changes within the cells and the development of cancer. The IDH1 mutations are remarkably specific to a single codon in the conserved and functionally important Arginine 132 residue (R132) in IDH1. This antibody is developed as a monoclonal antibody which can specifically detect R132S mutation of IDH1.
Additional Text
Purification
Protein A purified
Antibody Clonality
Monoclonal
10391 Datasheet
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