PE/Cy5 Anti-human CD44 Antibody *HI44a*
Catalogue Number: 104401M0-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 tests |
| Host name: | Mouse |
| Clone: | HI44a |
| Isotype: | IgG2a |
| Immunogen: |
Description
Description: The HI44a monoclonal antibody reacts with human CD44, a 85 kD transmembrane glycoprotein commonly expressed on the surface of leukocytes, endothelial cells, lymphohematopoietic cells, epithelial cells and hepatocytes. In many organisms, CD44 acts to positively regulate peptidyl-tyrosine phosphorylation, enhances peptidyl-serine phosphorylation and is a positive regulator of ERK1 and ERK2 cascade. Also, it acts in critical cellular pathways, namely, the interferon-gamma-mediated signaling pathway and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands such as Matrix metalloprotein- ases (MMPs), Collagen, Osteopontin and Hyaluronan. CD44 is a very popular antibody target, with over 40000 publications in the last decade. CD44 has been widely used in immunology research, typically serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to PE/Cy5 (ex/em = 565/666 nm). It is compatible with the 561 nm laser and 660/20 nm bandpass filter (for example, as in the Agilent Technologies NovoCyte).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
104401M0 Protocol
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations