PE/iFluor® 594 Anti-human CD45 Antibody *HI151*

PE/iFluor® 594 Anti-human CD45 Antibody HI151

Catalogue Number: 104521Y1-AAT

Manufacturer:	AAT Bioquest
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 tests
Host name:	Mouse
Clone:	HI151
Isotype:	IgG1
Immunogen:

Overview
Datasheets

Description

Description: HI151 is an anti-human monoclonal antibody that targets the CD45 antigen. CD45 (also known as Leukocyte Common Antigen (LCA) or PTPRC) is a 180 - 240 kD transmembrane protein that is expressed on the surface of cells like B cells, macrophages, granulocytes and NK cells. CD45 has been associated with essential biological processes like dephosphorylation, specifically protein dephosphorylation. Also, in some organisms, it plays a role in the upregulation of stem cell proliferation, is an inhibitor of cytokine-mediated signaling pathway and enhances hematopoietic stem cell migration. CD45 acts in vital cellular pathways, for example, the B cell receptor signaling pathway, positive regulation of antigen receptor-mediated signaling pathway and negative regulation of cytokine-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands like Src kinases. CD45 is a very popular antibody target, with over 50000 publications in the last decade. CD45 is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, particularly in the study of cell biology and neuroscience. This antibody was purified through affinity chromatography and conjugated to PE/iFluor® 594 (ex/em = 566/606 nm). It is compatible with the 561 nm laser and 611/31 nm bandpass filter (for example, as in the Luminex Amnis CellStream).

Additional Text

Antibody Clonality

Monoclonal

Storage Note

See Protocol|12 months

104521Y1 Protocol

104521Y1 MSDS

Price

£232.00

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