iFluor® 532 Anti-human CD47 Antibody *HIRH47*
Catalogue Number: 10470070-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | HIRH47 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | FC, IF |
Description
Description: HIRH47 is an anti-human monoclonal antibody that targets the CD47 antigen. CD47 (sometimes referred to as MER6, Integrin associated protein or Rh-associated protein) is a 42 - 52 kD multi-pass membrane protein that is found on the surface of cells like T cells. In some organisms, CD47 upregulates cell population proliferation, acts to positively regulate phagocytosis and is involved in the positive regulation of stress fiber assembly. In addition, it is a component of key cellular pathways, namely, the integrin-mediated signaling pathway and negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands like SIRP, Thrombospondin and CD61. CD47 is a fairly uncommon antibody target, with a little more than 5000 publications in the last decade. Even still, CD47 is often used in flow cytometry applications as a phenotypic marker for differentiation of cell types, particularly in the study of immunology. This antibody was purified through affinity chromatography and conjugated to iFluor® 532 (ex/em = 537/560 nm). It is compatible with the 532 nm laser and 575/36 nm bandpass filter (for example, as in the Thermo Fisher Attune NxT).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
10470070 Protocol
SUPPORT
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PRODUCT
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DELIVERY
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