iFluor® 594 Anti-human CD47 Antibody *HI172*
Catalogue Number: 104710C1-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 tests |
| Host name: | Mouse |
| Clone: | HI172 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | FC, IF |
Description
Description: HI172 is an anti-human monoclonal antibody that is specific for the CD47 antigen. CD47 (sometimes called Integrin associated protein) is a 42 - 52 kD multi-pass membrane protein that is found on the surface of cells such as granulocytes, platelets, endothelial cells and B cells. CD47 acts in critical cellular pathways, in particular, the negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis and integrin-mediated signaling pathway. In addition, in certain organisms, it downregulates Fc-gamma receptor signaling pathway involved in phagocytosis, upregulates T cell activation and acts to positively regulate inflammatory response. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands like SIRP, Thrombospondin and CD61. CD47 is a fairly uncommon antibody target, with a little more than 5000 publications in the last decade. Even still, CD47 is often used in flow cytometry applications as a phenotypic marker for differentiation of cell types, particularly in the study of immunology. This antibody was purified through affinity chromatography and conjugated to iFluor® 594 (ex/em = 588/604 nm). It is compatible with the 592 nm laser and 610/30 nm bandpass filter (for example, as in the Luminex Amnis ImageStream).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
104710C1 Protocol
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations