PE/iFluor® 700 Anti-human CD47 Antibody *B6.H12*
Catalogue Number: 104721X2-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 tests |
| Host name: | Mouse |
| Clone: | B6.H12 |
| Isotype: | IgG1, kappa |
| Immunogen: |
Description
Description: B6.H12 is an anti-human monoclonal antibody that is specific for the CD47 antigen. CD47 (sometimes called MER6, Integrin associated protein or integrin-associated protein) is a 42 - 52 kD multi-pass membrane protein that is located on the surface of cells like T cells, erythrocytes, epithelial cells and endothelial cells. CD47 acts in essential cellular pathways, for instance, the negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis and integrin-mediated signaling pathway. Also, in some organisms, it is involved in the positive regulation of stress fiber assembly, is a promoter of T cell activation and positively regulates phagocytosis. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands like CD61. CD47 is a fairly uncommon antibody target, with a little more than 5000 publications in the last decade. Even still, CD47 is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, particularly in the study of immunology. This antibody was purified through affinity chromatography and conjugated to PE/iFluor® 700 (ex/em = 566/708 nm). It is compatible with the 561 nm laser and 720/60 nm bandpass filter (for example, as in the Bio-Rad ZE5 Cell Analyzer).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
104721X2 Protocol
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations