mFluor™ Violet 540 Anti-mouse/human/rat CD47 Antibody *MIAP410*
Catalogue Number: 10473121-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 tests |
| Host name: | Mouse |
| Clone: | MIAP410 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC, IF |
Description
Description: The MIAP410 monoclonal antibody binds with mouse/human/rat CD47, a 42 - 52 kD transmembrane protein frequently located on the surface of b cells, thymocytes and epithelial cells. In many organisms, CD47 acts to positively regulate phagocytosis, is a promoter of cell population proliferation and enhances T cell activation. Also, it is involved with vital cellular pathways, for instance, the negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis and integrin-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with critical macromolecules/ligands like Thrombospondin, SIRP and CD61. CD47 is a fairly uncommon antibody target, with a little more than 5000 publications in the last decade. Even still, CD47 has a variety of applications in immunology research, often serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to mFluor™ Violet 540 (ex/em = 394/537 nm). It is compatible with the 405 nm laser and 510/50 nm bandpass filter (for example, as in the BD FACSCanto™ II).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
10473121 Protocol
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PRODUCT
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DELIVERY
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