mFluor™ Violet 540 Anti-non-human primates/ human CD49b Antibody *AK7*
Catalogue Number: 10491121-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 tests |
| Host name: | Mouse |
| Clone: | AK7 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | FC, IF |
Description
Description: The AK7 monoclonal antibody reacts with non-human primates/ human CD49b, a 170 kD member of the Integrin alpha chain family commonly located on the surface of activated T cells, B cells and monocytes. In some organisms, CD49b plays a role in the upregulation of alkaline phosphatase activity, is involved in the positive regulation of translation and is a promoter of epithelial cell migration. Additionally, it plays a role in essential cellular pathways, for example, the integrin-mediated signaling pathway and collagen-activated signaling pathway. CD49b has been associated with critical biological processes such as cell adhesion, specifically cell adhesion mediated by integrin, and is associated with a variety of biologically interesting macromolecules/ligands, for example, laminin, collagen and MMP-1. CD49b is a fairly uncommon antibody target, with a little more than 3000 publications in the last decade. Even still, CD49b is commonly used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of immunology. This antibody was purified through affinity chromatography and conjugated to mFluor™ Violet 540 (ex/em = 394/537 nm). It is compatible with the 405 nm laser and 510/50 nm bandpass filter (for example, as in the BD FACSAria™ III).
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
10491121 Protocol
SUPPORT
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PRODUCT
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DELIVERY
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