Polyclonal Antibody to APG16L
Catalogue Number: 11-10020-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | ATG16L1||APG16L||UNQ9393/PRO34307 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A partial length recombinant APG16L protein (amino acids 35-260) was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: ATG16L1/APG16L is part of a large protein complex that functions as a molecular scaffold mediating protein-protein interactions necessary for formation of the autophagosome in response to both classical and pathogen-related autophagy stimuli. APG16L protein contains an N-terminal Atg5-binding domain, a coiled-coil domain and a C-terminal WD (tryptophan-aspartic acid)-repeat domain. APG16L forms a complex with the Atg12 Atg5 conjugate and together they are actively translocated to the phagophore and are further elongated during autophagosome formation. Genetic variation in the APG16L gene has been recently implicated in Crohn's disease pathogenesis. Polymorphism within APG16L gene results in excessive production of IL-1beta and IL-6 culmunating in the inflammatory process in Crohn's disease.
Additional Text
Gene Name
ATG16L1
Uniprot ID
Q676U5
Gene ID
55054
Purification
Protein A purified
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 2-4 µg/ml
11-10020 Datasheet
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